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8 Although kidney-lung interactions have been discussed as possible mechanisms for this association, there is a gap in our knowledge on the impact of high oxygen supplementation and the development of AKI, especially in adult populations

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The GPR30 receptor agonist G1 inhibits ferroptosis and significantly improves chondrocyte viability and motor ability in mice through the YAP1/FTH1 pathway, while GPR30 receptor antagonist G15 has the opposite effect, suggesting that hormone-related ferroptosis may emerge as a promising target for alleviating osteoarthritis in postmenopausal women

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